Portable Chrome uses the host system’s drivers. If there’s no sound, ensure the host computer has audio drivers installed (most do). For microphone issues (Zoom/Meet), run the portable Chrome as admin (right-click → Run as administrator) – this gives it hardware access.
USB 2.0 is slow (480 Mbps). Upgrade to a USB 3.0 or 3.1 drive (blue internal plastic). For best performance, use a USB 3.2 Gen 2 SSD-style flash drive. Alternatively, copy the portable folder to the local desktop (if privacy isn’t a concern), run it, then delete it. download google chrome portable 64 bit