No. Once you save the settings and DLL, the game loads the emulation automatically. You only need x360ce.exe again if you want to change settings.
The original developers (x360ce team) host version archives on GitHub. x360ce 3.2.8.77 download
When prompted to search the internet for settings, select "Search automatically" and click Next . This will pull community-verified button mappings for your specific controller. x360ce 3.2.8.77 download
: It remains the preferred choice for older games (DirectX 9 era) where modern virtual driver methods might cause input lag or fail to recognize the game process. Setup Instructions x360ce 3.2.8.77 download