Do you have a parallel-port scanner or a USB 1.1 webcam from 2000? Modern 64-bit Windows lacks drivers for these. Virtual machines can't pass through parallel ports easily. Running Ulead Photo Express 3.0 SE natively on a 64-bit OS (via compatibility mode) is sometimes the only way to acquire images from ancient peripherals.
If you cannot get the ISO to work on your 64-bit system, consider these pivots: Ulead Photo Express 3.0 SE ISO 64 bit