Performance-wise, JNO runs significantly better on large vessels. Visually, with high-res textures and volumetric clouds (included or via mods), it rivals heavily modded KSP. Sound design is its only weak point; the engine sounds are functional but lack the visceral roar of KSP’s rocket noises.
While the "Sandbox" mode offers infinite parts and fuel for creative building, the Career Mode is where Juno: New Origins truly shines as a game. Juno New Origins