Windows Defender is deeply integrated into the OS. If you want to disable it permanently, a simple toggle in the "Settings" menu won't work—it will automatically turn itself back on after a restart. To truly "tweak" it out of existence, follow these steps. Step 1: Disable Tamper Protection (Mandatory)
Set-ItemProperty -Path "HKLM:\SYSTEM\CurrentControlSet\Services\WinDefend" -Name "Start" -Value 4 -Type DWord Set-ItemProperty -Path "HKLM:\SYSTEM\CurrentControlSet\Services\WdFilter" -Name "Start" -Value 4 -Type DWord Set-ItemProperty -Path "HKLM:\SYSTEM\CurrentControlSet\Services\WdNisDrv" -Name "Start" -Value 4 -Type DWord Set-ItemProperty -Path "HKLM:\SYSTEM\CurrentControlSet\Services\WdNisSvc" -Name "Start" -Value 4 -Type DWord Windows 10 Pro Tweak No Defender