Have you successfully set up RE4 on PPSSPP? Share your settings in the comments (without linking to ROMs).
When you see a link for a it almost certainly contains the game ISO or CSO inside. You cannot run a Zip file directly inside PPSSPP; you must extract it first. The "UPD" in your search query likely refers to "Updated," indicating you are looking for a verified, working version of the file, perhaps a compressed CSO to save space on your phone. Resident Evil 4 Ppsspp Zip File Download Android UPD
: Since a native PSP port never existed, these zip files contain an Have you successfully set up RE4 on PPSSPP