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A: Absolutely not. It requires Rosetta (PowerPC) which Apple removed after macOS 10.14 Mojave.

: The official QuarkXPress Installer Center typically only provides downloads for "fully supported" modern versions (2019 and later). Ways to Access QuarkXPress 5.0 Today Download Quarkxpress 5.0 Free

(for macOS Classic/OS X and Windows). Here's what you should know: A: Absolutely not